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Thus, larger clinical trials are necessary to approve novel antibodies in the treatment of specific tumors

Microfold (M) cells found in Peyers patches actively transport luminal antigens to the underlying lymphoid follicles to initiate an immune response, leading to autoimmune diseases [292], and play a role at the interface between innate and adaptive immunity [257]

Grace et al., 2019), and NADH:ubiquinone oxidoreductase core subunit 3 (MT-ND3) (Hattori et al., 2016), as well as the nuclear-encoded gene surfeit locus protein 1 (SURF1) (Inak et al., 2021)

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Genetic testing has increased our ability to make the diagnosis in uncertain cases but has not allowed us to predict a particular patient's natural history based on the mutation