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34 Risk factors for the development of hyperammonaemia whilst undergoing therapy with VPA include the concomitant use of other antiepileptic drugs, concomitant use of mood stabilizers, genetic variability, poor nutritional status, inborn errors in carnitine metabolism and errors in metabolism of urea, and the use of certain HIV medications

7,8 The liver interacts with almost all body systems

Tesoriero, C

Kim T, Shijo H, Kokawa H, Tokumitsu H, Kubara K, Ota K, et al

Bosch J, Thabut D, Bendtsen F, DAmico G, Albillos A, Gonzlez Abraldes J, et al

A third site, Site 3, at the bottom of the figure also sampled frequent contact with linoleic acid, but was not tested as a candidate for mutation given the sites proximity to the binding interface with the -subunit, reduced contact times compared to Sites 1 and 2, and the diffuse nature of the interaction surface