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Parumasivam T, Chan JG, Pang A, Quan DH, Triccas JA, Britton WJ, Chan HK

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

The effect of MOTS-c in preventing metabolic symptoms following a HFD was not due to reduced caloric intake or increased total activity, but was associated with increased body heat production [4], indicating thermal energy dissipation as a feasible caloric outlet

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The tumor microenvironment, in turn, can adapt to make it difficult for the immune cells or anticancer drugs to reach and eliminate tumor cells (104)Jin MZ, et al

Cell 54 , 641649 (1988)