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Desiree Granados Editorial Process Our Editorial Process John DiBella is the co-founder and CEO at The Sanctuary Wellness Institute

In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

But since they can inhabit the guts of animals, us humans can get our B12 intake from meat

Bottom Line 5A1MQ is a small molecule (~159 to 175 Da), not a peptide

Systemic : Inflammation regulation, damage repair, and inter-system communication (e.g., brain, gut, muscles, metabolism)