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Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure

Journal of Nutrition, 132, pp

[DOI] [PubMed] [Google Scholar] 29.Siliprandi N., Di Lisa F., Pieralisi G., Ripari P., Maccari F., Menabo R., Giamberardino M.A., Vecchiat L

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Acetyl L-carnitine exhibits superior blood-brain barrier penetration with brain tissue concentrations reaching 3-4 times higher than the propionyl derivative, demonstrating enhanced neuroprotective effects and neurotransmitter support through direct acetyl group donation for acetylcholine synthesis

Possibly the most impressive data relate to L-carnitine as a therapy for improving outcomes in acute myocardial infarction