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It may be possible to answer this question by analyzing what makes animals with similar genetic vulnerabilities different

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The various fates of cytosolic iron are likely determined by the activity of iron transporters, such as the mitochondrial iron importers (Mitoferrin 1 and Mitoferrin 2, FIGURE 1 COMPOSITION OF THE CYTOSOLIC LABILE IRON POOL From a conceptual standpoint, the cytosol must contain a kinetically labile, metabolically accessible pool of iron so that iron can be distributed to its various sites of utilization, transport, or storage (reviewed in Attempts have been made to characterize the molecular composition of the cytosolic LIP and some progress has been made

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Belloc F, Boisseau MR, Jalloustre C, Reiffers J, Bernard P, Lacombe F (1994) A Flow Cytometric Method Using Hoechst 33342 and Propidium Iodide for Simultaneous Cell Cycle Analysis and Apoptosis Determination in Unfixed Cells Cytometry 17: 5965