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This work showed that the inhibition of energy metabolism across all T cell differentiation states caused a strong decrease in protein synthesis, and the authors concluded that protein synthesis in TCR-activated and effector T cells was more dependent on glycolysis, whereas oxidative phosphorylation was more important for driving protein synthesis in naive and memory T cells

Ghoniem A

Another key pathway in vivo through which inflammation is closely related to oxidative stress and immune regulation is the Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) pathway

doi: 10.3390/biom10020195 40 BlackhurstB

Moreover, CD8 + T RM cells were correlated with AIH disease severity and significantly decreased after immunosuppression therapy [47]

inhibition of this pathway results in loss of intestinal crypts and tissue denaturation (Moparthi and Koch, 2019)