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This is the basis for twice-daily dosing

Mitochondria are responsible for producing the energy required for sperm motility, but during this process, some electrons leak from the electron transport chain and react with oxygen to form superoxide anions (56, 57)

The effect of oxidative stress-induced cell death was further assessed using cumene hydroperoxide (CHP) and H 2 O 2 as the oxidizing agents

Zhang H, Deng T, Liu R, Ning T, Yang H, Liu D, et al

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The article also deals at some length with nonenzymatic and enzymatic processes that divert glutathione S -conjugate and cysteine S -conjugate away from the mercapturate pathway