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Neuromuscular causes should be investigated only after ruling out nonneuromuscular causes and after considering whether potential benefits of a diagnosis outweigh the risks and expense of extensive testing

In this sense, searching for new therapeutic alternatives for reestablishing metabolic homeostasis is necessary

10.1074/jbc.M115.651737 J

It is crucial to develop more efficient methods to evaluate metabolic abnormalities that raise CVD risk as the obesity and diabetes epidemics sweep the world

We include vitamin D3, since vitamin D receptors are most concentrated in the highest functioning areas of the brain and it is essential for optimum brain function as we age