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[47] reported similar findings, showing that the AMPK activator metformin increased LDLR expression in HepG2 cells through both SREBP-2-dependent and independent mechanisms

Urinary sulfate excretion was reduced up to 95% by feeding low-methionine diets to rats, and a 60% decrease in liver methionine was observed, [14]
& Perez-Ballester, B

Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells

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It means it should be framed as unfinished
