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doi: 10.1007/s12374-018-0350-x 197 TubielloF

Challenges in scalable, GMP-compliant manufacturingparticularly batch-to-batch variability in encapsulation efficiency (2194% for PLGA NPs)and long-term biocompatibility assessments (e.g., hepatosplenic accumulation, PEG immunogenicity) remain unresolved

At the same time, the review does not overlook the challenges associated with hydrogen-assisted extraction

Future studies should adopt targeted designs to mitigate these issues: Confounding by coexisting nutrient deficiencies: mineral deficiencies [e.g., zinc (344)] or vitamin deficiencies [e.g., vitamin D (169, 347349)] often co-occur with protein or fiber deficiencies

Oncogenic pathways and the electron transport chain: A dange ROS liaison

Apoptosis was triggered via alternative pathways (Hasson et al