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These effects include breaks in genetic material, formation of DNA adducts, and oxidation of bases.[20] Additionally, serum concentrations of inflammatory cytokines and pro-oxidant biomarkers such as glutathione, 4-hydroxynenal, and malonaldehyde were found to be higher in postmenopausal women than in premenopausal women.[21] The elevation of cytokines and pro-oxidant makers suggests that there is a high degree of oxidative stress in the postmenopausal state.[21,22] Cardiovascular effects of menopause Estrogen has been shown to play a physiologic role in the cardiovascular system by protecting against heart disease

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