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Moshiri and Oryan, 2011)

Standard stock solutions (5 mM L 1 ) were prepared by dissolving in 250 mM dithiotreitol

18 F-FDG-PET: 18 F-fluorodexyglucose positron emission tomography GAD: Glutamate decarboxylase GADA: Gamma-aminobutyric acid GCase: Glucocerebrosidase GCH1: GTP-cyclohydrolase GDNF: Glial cell-line derived neurotrophic factor GLP1: Glucagon-like peptide-1 GSR: Global symptom relief HDRS: Hamilton Depression Rating Scale hESCs: Human embryonic stem cells HLA: Human leucocyte antigen hPSCs: Human pluripotent stem cells HSP: Heat shock protein iPSCs: Induced pluripotent stem cells LRRK2: Leukine-rich repeat kinase 2 LV: Lentivirus MADRS: Montgomery-sberg Depression Rating Scale MCI: Mild cognitive impairment MesDA: mesencephalic dopaminergic MRgFUS: Magnetic resonance imaging-guided focused ultrasound MRI: Magnetic resonance imaging NRTN: Neurturin PD: Parkinsons disease PDQ-39: Parkinsons disease questionnaire 39 PET: Positron emission tomography RA: Receptor agonist RNA: Ribonucleic acid ROC: Ras-of-complex ROS: Reactive oxygen species rTMS: Repetitive transcranial magnetic stimulation STN: Subthalamic nucleus T2DM: Type 2 diabetes mellitus TH: Tyrosine hydroxylase TMS: Transcranial magnetic stimulation UPDRS: Unified Parkinson Disease Rating Scale -synuclein : -syn References Aflaki E, Westbroek W, Sidransky E

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Possible Side Effects FOXO4-DRI has been evaluated almost exclusively in preclinical and animal studies, with limited safety data in higher organisms

10.1146/annurev-pathol-020712-163918 103 MyungN