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These barriers span from molecular drug properties and cellular adaptive responses to tissue-level heterogeneity and, ultimately, the clinical therapeutic index (Fig

10.2147/JIR.S456000 3 ArjmandB.Alavi-MoghadamS.Parhizkar-RoudsariP.Rezaei-TaviraniM.Tayanloo-BeikA.GoodarziP.et al

10.3389/ftox.2022.885843PubMed Abstract | CrossRef Full Text | Google Scholar 5 AlmalkiA

Dose increase: at Day 16 inside the on phase, the dose steps from the low end to the high end of the range

doi: 10.1104/pp.112.3.1071
