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Organic hydroperoxides can be reduced to corresponding alcohols in the reaction catalyzed by GPx as well as due to the peroxidase activity of Se-independent glutathione S-transferases that also use GSH as the cosubstrate: Glutathione reduces oxidized glutaredoxin that is formed during the reduction of disulfides [5]
doi:10.1016/j.ejim.2025.04.024 d'Entremont MA, Poorthuis MHF, Fiolet ATL, et al
It can influence the activation of transcription factors such as NF-B, which is involved in inflammatory responses and cell survival
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