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Nausea, vomiting, diarrhea, constipation, and decreased appetite have all been reported, with frequency and severity dependent on dose and titration schedule

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According to Harvard Medical School, people with cobalamin deficiency may experience subtle but unusual and progressive signs of illness, including strange tingling or numb sensations, difficulty walking, cognitive and memory issues, and weakness

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The emulsifying agent, carboxymethylcellulose, has been reported to alter the intestinal microbiota and promote chronic inflammation, and polysorbate 80 has been found to have an erosive impact on the intestinal mucosal layer (Chassaing et al