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From the study of new phenyl dihydrouracil (PD)-based PROTACs designed by this group, PD-PROTAC 113 (SJ43489) stands out, capable of degrading the LCK protein (DC 50 = 0.8 nM) and inhibiting the cell viability of KOPT-K1 cells with nanomolar potency (IC 50 = 37 nM) 156

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Monitor LFTs in all patients during therapy at roughly 6-month intervals or when clinically indicated

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A marked reduction in - and -secretase function and BACE1 and APP expression was observed [57]