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2.1.5 IL-22 Several studies have shown that the expression of the Th22 cell cytokine IL-22 is elevated in pruritic PN lesions, which is potentially associated with impaired epidermal proliferation and differentiation and skin inflammation (27, 51)
Regarding hippocampal activity, the hypothesis of the inverted U-shaped trend is becoming popular among the scientific community

[DOI] [PubMed] [Google Scholar] 238.Liu L, Belkadi A, Darnall L, Hu T, Drescher C, Cotleur AC, Padovani-Claudio D, He T, Choi K, Lane TE, et al
Antioxidants 12 , 785 (2023)

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Keratinocytes as depository of ammonium-inducible glutamine synthetase: Age- and anatomy-dependent distribution in human and rat skin
