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Fan JP, Kim HS, Han GD

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Especially under ischemiareperfusion conditions, reducing the level of acylcarnitine has a significant effect on the energy metabolism of the heart and the maturity and proliferation of cardiomyocytes because reducing the utilization of fatty acids and increasing the reliance on glucose oxidation as an energy source can promote the recovery of myocardial function at a lower rate of oxygen consumption

doi:10.3389/fncel.2019.00353

Specifically, robust evidence from large-scale, multicenter randomized controlled trials is still needed to conclusively establish efficacy, determine optimal dosing and timing strategies, and fully evaluate safety before widespread clinical adoption in RDS management can be recommended