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Similarly, several novel MCT1/4 inhibitors are under investigation, including AZD3965, which has demonstrated anti-tumor effects by inhibiting MCT1, disrupting lactate metabolism in tumors, and causing lactate accumulation within cancer cells

Vaccine 33:61736177 [DOI] [PubMed] [Google Scholar] 79.Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, Neri S, Vacante M, Cammalleri L, Motta M (2008) Acetyl l-carnitine (ALC) treatment in elderly patients with fatigue

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Over time, this can contribute to a worsening overall skin condition

This can ultimately contribute to the destabilization of mitochondrial complexes I and III due to the combined effects of oxidative stress, genetic mutations, altered lipid composition, decreased coenzyme Q10 levels, and impaired mitochondrial dynamics