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The final group was treated with l-carnitine (25 mg/kg/i.p.) and ketotifen (4 mg/kg/i.p.) after the morphine administration

10.12779/dnd.2017.16.1.26 18

Despite the fact that many higher doses have been tried without any negative effects and may be safe, the data for ingestion beyond 2000 mg/day are insufficient to make a confident judgement of long-term safety [67,68]
one observational study found 37% of fibromyalgia patients had diagnoses associated with LUTS, often in addition to IBS and/or generalized anxiety disorder

doi: 10.1016/S2213-2600(21)00031-X
