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This accumulation activates the innate immune response via NLRP3 inflammasome-mediated IL-1 production, further propagating inflammation

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Following optimization, patients entered a stabilization period of 4 to 8 weeks, during which PS usage had to match prescribed volumes and oral fluid intake and urine output were required to remain within 25% of baseline levels

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Early Human Data (Limited) A small number of exploratory human studies have examined: gastrointestinal-related applications (BPC-157) inflammation or tissue-response markers in specific controlled settings These studies generally involve small sample sizes and limited endpoints