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This phenomenon can, at least in part, be explained by excessive desensitization at the 2 -AR

Metformin decreases the expression of vegf-a and ctgf-1 and improves histological, ultrastructural and hormonal changes in adult rat polycystic ovary
Implementation of pre-prescription genotyping and individualized warfarin therapy represents an opportunity to minimize the risk of haemorrhage without compromising effectiveness

Wtjen, W

New Trends Clin Neuropharmacol 1989;3(2):131-132

Antioxidants 12 , 967 (2023)
