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Protein or zinc deficient diets can alter copper metabolism, so a malnourished individual might observe different outcomes than someone with adequate nutrition
So that is a great place
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Fasted AM: First thing in the morning, before eating, insulin is naturally low a clean window for a second pulse in a twice-daily schedule
Proc Natl Acad Sci USA 100:39833988 Aoki J, Inoue A, Okudaira S (2008) Two pathway for lysophosphatidic acid production
Not dramatic, not overnight, but consistently better over time
