glutathione disulfide antioxidant - an overview Myocardial oxidant and antioxidant chemistry.

10.1073/pnas.97.13.6947 [DOI] [PMC free article] [PubMed] [Google Scholar] Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, and van Dam AP (2008)

This protective response might be an attempt to reduce the levels of oxidative stress but alternatively might accelerate ferroptosis in case of excessive HMOX-1 activation [30]

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The Woodlands Healing Research Center in Philadelphia, USA says glutathione must be in the reduced form to work properly and that the un-reduced form is much cheaper and isn't metabolically active