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Although beneficial in tumor cells, GPX4 inhibition can also trigger ferroptosis-induced death of immune cells in the tumor microenvironment leading to ineffective antitumor response

New technologies are allowing selective identification of subsets or sub-states of reactive astrocytes, and have identified a role for a potentially therapeutically targetable mechanism that limits XBP1-driven pathogenic astrocyte responses

SR, JAW, LR, and VA cared for the animals, collected tissues and plasma, recorded body weights, and performed the gene and protein expression assays

A practical HPLC method to measure reduced (GSH) and oxidized (GSSG) glutathione concentrations in animal tissues

This shift in fatty acid composition may lead to the formation of morphologically normal intercellular lamellae that are functionally impaired, contributing to an incomplete skin barrier [27]

In fact, heart palpitations after eating are quite common