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The exact mechanism by which gut microbiota influence hypertension is not fully understood, but their link has recently been the subject of numerous animal and human studies (129, 130)
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Further, in vivo imaging studies in mild AD patients revealed a decrease in the cholinergic activity in brain areas typically affected by AD, such as the precuneus and the posterior cingulate cortex [97,98], especially in very early stages [99]
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