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During periods of fasting, when glucose is scarce, medium-chain fatty acids are increasingly mobilized from adipose tissue and oxidized for energy

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These proteins are activated through the carboxylation of glutamate, a process reliant on the oxygenation of vitamin K hydroquinone (Fasco et al

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For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)