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389 Natural compounds such as resveratrol, which induces autophagy through SIRT1 activation, 390 and spermidine, a polyamine that enhances autophagic flux, further demonstrate the therapeutic potential of autophagy induction in NDDs

MOTS-c has a 24 hour half-life with effects lasting 1224 hours via AMPK phosphorylation

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Modulation of HIF-1 and its upstream and downstream genes may contribute to the pathological processes of angiogenesis, inflammation, and complications such as calcinosis in DM patients (185, 189)