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Vitamin B12 supplementation may be helpful for people at risk of deficiency, such as those on vegan diets, patients with certain gastrointestinal conditions, or those taking metformin

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doi: 10.1210/jcem.76.6.8501156

NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability