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The result of worsened outcome due to chronic stress could be the result of activation of HPA (hypothalamic-pituitary-adrenal), as well as SNS (sympathetic nervous system) (Nusslock and Miller, 2016), and microglial activation (Kosten et al., 2012

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Additionally, Rad51-functional immature hepatocytes proliferate vigorously in a ROS-related chronic inflammatory microenvironment, triggering ductal reaction and transdifferentiation of cholangiocytes into hepatocytes, thereby increasing malignancy and ultimately leading to HCC [107]

Blood 110: 21662172, 2007 [DOI] [PMC free article] [PubMed] [Google Scholar] 187.Walker JA, Hall AM, Kotsopoulou E, Espeli M, Nitschke L, Barker RN, Lyons PA, and Smith KG

Antibody conditioning enables MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance
