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In the Kmt2d +/Geo mouse model, treatment with KD for 2 weeks normalizes the global histone modification state corrects the neurogenesis deficiency in the granule cell layer of the dentate gyrus, and rescues the hippocampal memory defects (88)

This trans-cellular transport generates a 4-fold plasma-to-CSF ascorbate gradient in rats [45,52], resulting in CSF concentrations of about 200-400 M [53,54], compared to plasma concentrations of 60 M or less (Fig

Excessive microglial cell activation causes the release of interleukins, interferons, and TNF- due to leakage of BBB, which may further cause neuronal death [134,135,136]

In vitro and animal studies suggest DIM has anti-inflammatory 17 and chemoprotective effects

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Are my digestive symptoms more consistent with inflammation, infection, IBS, food intolerance, medication effects, or another condition