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Metabolism and Duration of Action Many natural compounds have longer biological effects than their plasma halflives would suggest, either due to active metabolites or lasting changes in gene expression

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doi: 10.1016/j.jtho.2016.11.293 CrossRef Google Scholar View reference in article 54 SocinskiMAJotteRMCappuzzoFOrlandiFStroyakovskiyDNogamiNet al

It is therefore recommended that future research be carried out on validating these biomarkers using large cohort studies in order to determine the diagnostic accuracy and clinical relevance of these biomarkers

In another oxidative stress-induced apoptosis model, 6-Hydroxydopamine (6-OHDA) was used as an inducer in catecholaminergic PC-12 cells, and significant neuroprotective effects against apoptosis were reported, even better than the green tea polyphenol mixture [92]