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A striking selectivity for AR binding sites based on the presence of adjacent binding motifs emerged in studies in which SUMO2 and 3 activity was inhibited pharmacologically: SUMOylation inhibition using ML-792 inhibited AR binding to genomic regions that contain multiple AREs, but enhanced AR binding to less accessible AREs that are enriched for pioneering transcription factor binding sites

[DOI] [PubMed] [Google Scholar] 225.Giacco, F

doi: 10.3390/biom11111624 103

[DOI] [PubMed] [Google Scholar] 22.Gulcin I

Enhanced with L-tyrosine, ashwagandha root, adrenal extract, and nutritional yeast

doi: 10.1111/j.1742-7843.2009.00480.x