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Serrano M, Hannon GJ and Beach D (1993) A new regulatory motif in cellcycle control causing specific inhibition of cyclin D/CDK4

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Only in the last three years, also as a result of the greater understanding of the regulation of the anthocyanin biosynthetic pathway, have the natural allelic variations been uncovered that are responsible for the Aft and atv phenotypes

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Possibly, upon accumulation in cardiac tissue, MNPs trigger oxidative stress trough ROS production, activating the NLRP3 inflammasome and JAK1/STAT3 pathways, which promote inflammation, endothelial dysfunction, thrombosis and atherogenesis, ultimately leading to increased risk of myocardial infarction and stroke