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scavenging mitochondrial ROS or inhibiting complex III attenuated these effects without affecting Smad signaling, confirming a Smad-independent mitochondrial mechanism [63]

To further evaluate the role of SFN in the IMQ-induced psoriasis mouse model, histopathological analysis of mouse dorsal skin was performed by H&E staining (Fig

1.1.1.2.2 Ceruloplasmin Ceruloplasmin oxidizes Fe 2+ to Fe 3+ to prevent the Fenton reaction and hydroxyl radical formation [22]

Mechanisms of acetaminophen-induced liver necrosis