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Interestingly, various sphincter failures [10,64,110,111,113,180] were recovered, and glaucoma-mydriasis [110,113], atropine-mydriasis, L-arginine-induced prolonged miosis, and L-NAME-induced prolonged miosis [111] were counteracted

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found that the abnormal accumulation of double-stranded DNA in the cytoplasm may bind to the cytoplasmic DNA sensor (cGAS), thereby specifically triggering the STING-interferon (IFN) signaling pathway in microglia, promoting the expression and secretion of inflammatory cytokines

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However, these combination effects are highly dependent on experimental models and co-administered components: synergistic metabolic improvements have been observed in animal studies (80), whereas some human studies report only modest reductions in liver enzymes without significant changes in broader metabolic parameters (64)

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