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Patient Scenario 1 A 77-year-old female with a history of intrahepatic cholangiocarcinoma, hypertension, and stage IV kidney disease with an estimated glomerular filtration rate (eGFR) of 22 who was diagnosed after routine laboratory examinations showed elevated alkaline phosphatase and total bilirubin 3.4 mg/dL

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Risk of bias at the study were performed for each outcome (and, where relevant, at specific time points) with respect to the effect of assignment to the intervention (i.e., an intention-to-treat effect)