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conducted a study involving 54 healthy adult males and reported that long-term oral glutathione (GSH) supplementation led to an increase in GSH levels in both blood and red blood cells and a reduction in oxidative stress [55]
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Additionally, Chiharu et al
However, As 3+ , despite being an inducer of oxidative stress, induced GCLC transcriptional activity by a mechanism that is independent of Nrf1 or Nrf2 [87]
Rat liver cytosolic GSH turns over rapidly with a half-life of 23 hours
doi: 10.1136/bmj-2023-075230 86
