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Chem Biol Interact 2019;310:108754

Block 4, Question 8 Explanation Correct Answer: B

To avoid this issue, Lahnsteiner [3] was able to stabilize the thioether bond by placing a vicinal amine that led to the nucleophilic attack and hydrolysis of the thiol-maleimide conjugate, resulting a stable six-membered ring that eliminated the possibility of the retro-Michael conversion (Fig

DNA methylation of FRGs is involved in the regulation of their expression

Jiang Z-Y, Woollard AC, Wolff SP

Specifically, cisplatin is highly active on thiol-containing molecules such as glutathione, and its depletion leads to the accumulation of ROS [52], which in turn leads to the activation of apoptosis [53]