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Overall, although the [ 11 C]Ro15-4513 V T reflects the net effect of the availability of these different GABA-A receptors, the 20-fold greater affinity of [ 11 C]Ro15-4513 for 5-GABA A Rs and the enriched expression of 5-GABA A Rs in the hippocampus indicates the lower [ 11 C]Ro15-4513 hippocampal availability is likely to predominantly reflect lower 5-GABA A R levels

[PMC free article: PMC185985] [PubMed: 8675645] 873

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This communication is important to minimise any adverse side effects or drug interactions that may occur (540)