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It is the most popular skin lightening agent in Japan because of its ability to inhibit melanin production by inhibiting tyrosinase activity

Doctors use them to treat various medical ailments

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130,140 Nevertheless, it is not FDA-approved for this use

And Pinealon studies are predominantly preclinical

PMID: 1541673 [Para 241 ] James SJ, Cutler P, Melnyk S, Jeraigan S, Janak L, Gaylor D, and Neubrander J, Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism, The American journal of clinical nutrition 2004;80:1611-7