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1 Introduction Epigenetics, originally coined by Waddington to describe gene-environment interactions shaping phenotypes, now refers to heritable changes in gene expression that occur without alterations in the underlying DNA sequences (Waddington, 2012

1059 For complex IV and ATP synthesis, inhibitors such as resveratrol and oligomycin have shown promising antitumor activity in skin cancer, neuroblastoma, and lymphoblastic leukemia models

Keywords: CYP2D6 , risperidone, polymorphisms, adverse drug reaction, pharmacogenetics, pharmacokinetics, pharmacodynamics Introduction Risperidone is an atypical antipsychotic (AAP) drug that is being prescribed for the treatment of irritability or aggression in autism, schizophrenia, and acute bipolar mania

RESEARCH DESIGN AND METHODS We infused 12 diabetic patients and 12 nondiabetic control subjects with [ 2 H 2 ]-glycine to measure GSH synthesis