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In fine, it must be recognized that all these animal experimental models allow us to study the pathogenesis of emphysema in stable or exacerbated phases and the effects of specific genetic changes on disease development and progression and offer the opportunity to assess the potential effects of various therapeutic interventions such as anti-inflammatory agents, antioxidants, and other protective agents

Insulin resistance enhances the brain metastasis of breast cancer and mediate EMT through the adipocyte-derived exosomes [91]

In line with this model, alanine replacement of multiple aromatic, leucine, and/or acidic residues (e.g., the m7 WRDGQ-AAAAA and m14 EDQET-AAAAA variants) strongly impaired PIF4-mediated transcription in yeast (Supplementary Fig