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Hepatocytes and skeletal muscle benefit from PPAR- s promotion of -oxidation, which lowers hepatic lipid buildup (182)

Nonetheless, bone loss occurs across both compartments during aging

For example, IMiDs derivatives for click-chemistry can be constructed by S N Ar reactions between amine-terminal alkine or azide-based linkers and fluorinated thalidomide derivatives, leading to compound 119 83,132,171

Weight changes are usually water/glycogen

Nat Rev Drug Discovery 18:295317 Cui Z, Zhao X, Amevor FK, Du X, Wang Y, Li D, Shu G, Tian Y, Zhao X (2022) Therapeutic application of quercetin in aging-related diseases: sirt1 as a potential mechanism

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