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Most protocols recommend two to four weeks off after each four to eight week treatment cycle

Multi-organ histopathology: Published histopathology data is often limited to the target tissue of each efficacy study

For non-reversible treatments, we under-treat first by design and add more at follow-up

While the reason for failure is specific for each therapeutic approach, many can be attributed to the classic challenges of drug delivery: failure to deliver the therapeutic to the target tissue at the necessary doses and for the required duration, while avoiding degradation and delivery to off-target tissues (Bader and Putnam, 2014)

Ausreichend ist eine Zyklus-Pause von 48 Wochen zwischen zwei TB-500-Kuren