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Tryptophan synthase The final step of tryptophan biosynthesis (Figure 4) is catalyzed by tryptophan synthase or TrpAB (EC 4.2.1.20), which is one of the first enzymes known to catalyze two different reactions in two separate active sites connected to each other via a tunnel on the interior of the protein (Leopoldseder et al., 2006

These ion channels play a critical role in modulating many aspects of neuronal physiology (i.e., intrinsic excitability, dendritic integration, tonic firing frequency, spike frequency adaptation, and action potential repolarization)

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Additionally, to verify whether caffeine could also show effects unrelated to salsolinol generation, we verified its activity on the enhancement of mesolimbic DA transmission mediated by exogenous salsolinol, as well as by another receptor agonist, morphine

10.1042/0264-6021:3430281 Biochem
