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In RBCs, Prx2 can bind to Hb under OS conditions to stabilize its structure and prevent Hb aggregation [79]

Accordingly, the increase in glutamine uptake (and glutamine activity) caused by ELAVL1 knockdown was accompanied by a two-fold increase in glutamine dependency for oxygen consumption (Fig

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Finally, a pervasive sense of being overwhelmed by the cumulative burden of these multisystem symptoms can serve as a valuable clinical indicator for nociplastic pain [12, 75]

By tailoring treatment strategies to individual health profiles and continuously monitoring IGF-1 levels throughout therapy, healthcare providers can enhance the effectiveness of the treatment