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Neural stem progenitor cells require NAMPT for cell cycle progression

This HTS protocol seems biased to detect compounds targeting aggregated structures rather than monomeric proteins, which represents a clear advantage for its potential therapeutic use since they would only target pathological -Syn assemblies without interfering with the activity of the soluble and functional protein

doi: 10.1073/pnas.1920310117

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(13) This illustrates the importance of metabolic canalization and how cellular metabolism depends on the structural organization of the enzymes and intermediates, forming microcompartments

Rapid resolution of large bowel diarrhea after the administration of a combination of a high-fiber diet and a probiotic mixture in 30 dogs