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REIMAGINE 2 a 68-week efficacy and safety phase 3 trial of once-weekly CagriSema 2.4 mg/2.4 mg versus semaglutide 2.4 mg, cagrilintide 2.4 mg, and placebo, and CagriSema 1.0 mg/1.0 mg versus semaglutide 1.0 mg and placebo in 2,728 adults with type 2 diabetes inadequately controlled with metformin with or without an SGLT2 inhibitor

Stage 3: The Exhaustion Phase (Burnout) In the final stage, the central nervous system significantly downregulates the HPA axis signaling to conserve energy and prevent further damage
doi: 10.1146/annurev.pharmtox.43.100901.135823

Chem 5 , 786804 (2019)

R., and Stanley T
